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The high-mobility group box-1 (HMGB1) protein is a pro-inflammatory nuclear protein that is passively released and targets Toll-like receptors (TLR) to alert the immune system of dying cells (Lotze and Tracey 2005

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The most researched in plants is indole-3-acetic acid (IAA), present in young growing cells in shoot tips and leaves and in developing flowers, seeds, and roots (Sheldrake, 2021)