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The first cardiovascular study of NNMT enzyme inhibition in a heart failure with preserved ejection fraction (HFpEF) mouse model demonstrated that treatment markedly reduced 1-MNA (by 77.1%), 2PY (by 66.2%), and 4PY (by 71.1%) in cardiac tissue, while improving cardiac function, enhancing global longitudinal strain, reversing peak longitudinal strain rate, and significantly reducing left ventricular hypertrophy and fibrosis

The convenience of alternative routes must be weighed against potentially reduced efficacy

[5] Glutathione supplementation is generally considered safe with a low risk of adverse effects when used at typical supplementation doses

[DOI] [PubMed] [Google Scholar] 3.Lenaz G., Fato R., Di Bernardo S., Jarreta D., Costa A., Genova M.L., Castelli G.P