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It serves as a cornerstone of the FDAs post-marketing safety surveillance initiative for pharmaceuticals and therapeutic agents, operating as a classic spontaneous reporting system

Furthermore, the activation of TLR4 in macrophages may play a role in the instability and rupture of plaques [164, 165]

Common symptoms include gastrointestinal issues such as nausea, constipation, diarrhea and heartburn

You may experience signs of stomach paralysis, including: Indigestion Nausea and vomiting Bloating Feeling full quickly or for a long time after eating Appetite loss Acid reflux and heartburn Constipation Blood sugar fluctuations Throwing up whole pieces of undigested food Upper belly pain If you leave it untreated, it can lead to malnutrition, dehydration, and a blockage in the bowels