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Plasminogen-related growth factors

Rouhier et al., 2005)

Severe inflammatory bowel disease including active Crohn's disease or ulcerative colitis, and gastroparesis a condition that causes delayed stomach emptying are conditions that typically preclude GLP-1 treatment because the medications further slow gastric emptying

The finding suggests that liraglutides cardiovascular benefits may be underappreciated, study populations and contexts matter (in higher-risk patients, differences in efficacy may be more pronounced), and/or that real-world effectiveness may differ from efficacy in selected trial populations, they say