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Semaglutide is a GLP-1 receptor agonist that works by reducing appetite, slowing digestion, and improving how your body manages blood sugar

These aspects likely need to be elucidated in future trials

Inclusion criteria require patients aged 18 and older with clinical UC diagnosis, moderate to severe active disease (mMS 5 with MES 2), recent surveillance colonoscopy ruling out dysplasia or cancer, and history of inadequate response or intolerance to at least 2 UC therapy classes, while excluding those with CD, fulminant colitis, disease limited to rectum, prior colectomy plans, or previous PD-1/PD-L1 exposure

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