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They are mainly located on chest, stomach, and extremities

One example is retatrutide, a triple agonist targeting GLP-1, GIP, and glucagon receptors, which demonstrated statistically significant weight loss (22.8-24.2%) and metabolic improvements in systolic and diastolic blood pressure and levels of glycated hemoglobin, fasting glucose, insulin, and lipids in a 48-week phase 2 trial, highlighting its potential for future obesity management

It tends to form the highly reactive hydroperoxyl radical (OOH) under acidic conditions

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