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A more useful definition of healing includes: Restored function under load Improved tissue resilience and tolerance Reduced frequency of flare cycles Improved movement confidence Reduced reinjury risk When therapy supports all of these, it becomes truly regenerative

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Several other genes present on chromosome 21, including SOD1 and APP are directly or indirectly involved in mitochondrial function, contributing to oxidative stress (Izzo et al., 2018) and may thus on their own or in combination with others have an impact on CBS expression and/or activity