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One study reported that niacin supplementation decreased the risk of ultraviolet light (UV)-induced skin cancers in mice, despite the fact that mice convert tryptophan to NAD more efficiently than rats and humans and thus do not get severely deficient (60)

Twice-daily dosing has been used in some acute-phase protocols where intensive early exposure is the design goal

Niacin at doses of 1.5 to 5 g/day has resulted in a few case reports of blurred vision and other eye problems, which have generally been reversible upon discontinuation (41)

McCulloch typically uses 1,5002,000 mg/day clinical protocols often adjust from research doses based on patient presentation, tolerability, and the broader supplement strategy