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The next step from there might be one of the older, less potent weight-loss drugs, such as phentermine

Weighted cumulative incidence for MACE, from Lambourg et al , Am J Kidney Dis, 2025 Cause-specific mortality Stopping metformin was associated with an increased risk of respiratory death (HR 1.51, 95% CI 1.06-2.12) but not cancer mortality (HR 1.07, 95% CI, 0.80-1.44)

Patients should inform their healthcare provider about all treatments they are undergoing

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