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We consistently recommend 2 mL as the optimal balance: doses remain measurable with standard 1 mL insulin syringes, and the final concentration avoids both extreme dilution and extreme viscosity

Autocrine and paracrine role of IGF-1 in breast cancer In contrast to the serum IGF-1 expression findings described above, increased IGF-1 mRNA levels within tissue samples may confer a favorable outcome and have been associated with increased disease-free survival (DFS) in patients with diagnosed estrogen receptor positive (ER + ) breast cancer [44]

BMJ 2009;339:b4731.ArticlePubMedPMC 49

It might also present with vision problems, ringing in ears, dilated neck veins, eye pain, difficulty swallowing and/or bleeding from gums or nose