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The regulation of NSC proliferation, self-renewal, and differentiation is finely regulated by changes in the surrounding microenvironment, or niche, in which NSCs reside (reviewed in Hepatocyte growth factor contributes to the maintenance of self-renewal and proliferation of NSCs in SVZ, which express MET and produce HGF

The scientific literature comprises over 300 peer-reviewed publications, with a notable acceleration of research since the pioneering work of Sosne and Kleinman on regenerative effects in the 2000s

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