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Did ASM result in any unintended consequences, including adverse selection of patients, access problems, cost shifting, evidence of stinting on appropriate care, anti-competitive effects on local health care markets, evidence of inappropriate referrals practices

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Researchers conducting dose-response studies or pilot experiments can reduce costs by starting with smaller batch sizes a single 5mg vial supports 50 doses at 100mcg each, sufficient for initial titration phases before committing to larger orders

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