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Importantly, deletion of eosinophil-derived IL-4 only ameliorated lesion development, without preventing disease progression (Lee et al, 2020

For sorting, mononuclear cells were reacted with anti-CD38 PE and anti-CD138 FITC antibodies and primary MM cells were isolated using fluorescence-activated cell sorting (BD FACSAria II, San Jose, CA, USA)

to conclude an MC4R agonist is not likely to produce clinically meaningful weight loss at well-tolerated doses, and the program was terminated after negative phase II results (48)

Lipid panels provide insight into cardiovascular risk factors that may improve as body composition changes