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It is composed of glutamic acid, cysteine and glycine and exists in almost every cell of the body

(PubMed) Andorfer JH, Tchaikovskaya T, Listowsky I

Based on Phase 2 studies, the initial dose may begin at 1 mg to 2 mg (0.0750.15 mL) once weekly, with gradual titration every 4 weeks in increments of 2 mg to 4 mg, as tolerated, up to a maximum of 12 mg (0.90 mL) weekly Doses between 4 mg and 12 mg weekly demonstrated meaningful reductions in body weight and glycemic parameters over 16 to 28 weeks

But as the lengthy history shows from the Gila monster discovery in the early 1990s to FDA approvals spanning nearly two decades these medications have been rigorously researched