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It also accounts for the cumulative risk of contamination from multiple punctures

Prevention and treatment of copper deficiency in sheep

BioMed Research International 2021:9924314

Signs of contamination or degradation: Cloudiness or turbidity (potential bacterial growth or precipitation) Visible particles or crystals (potential contamination or degradation products) Discolouration or browning (potential oxidative degradation) Visible mould growth (rare, but indicates severe contamination) Unpleasant or unusual odour (potential bacterial contamination) Action: If any of these signs are observed, discard the vial immediately