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While melatonin has a direct effect on oxidative stress by scavenging ROS and RNS (1), its metabolites (product of its degradation) are also active and act indirectly by inducing the production of anti-oxidative enzymes and lowering the synthesis of pro-oxidative molecules (2) leading to an overall reduction of oxidative stress

Therefore, alterations in GM can impact bile acid metabolism by engaging receptors or directly affecting bile acid synthesis, leading to disorders in bile acid metabolism ( Figure 3 )

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