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Clinical Trials and Translational Research Although preclinical data are promising, the translation of combination therapies into clinical practice is still in its early stages

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Although small molecule or peptide-based inhibitors against individual NSPs have been extensively explored in the past 50 years, efforts of the pharmaceutical industry so far have created little impact in the clinic, except for AAT augmentation therapy in patients with emphysema and congenital AATD (191)