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PLoS One 2014;9:e108152

So, we recommend using SL vitamin B12 rather than oral and IM, especially in patients who do not tolerate IM injection and patients who need prolonged vitamin B12 supplementation, such as patients with long-term metformin use and patients with pernicious anemia or with gastro-duodenal resection [51,52,53,54]

A., Britt E

Orforglipron produced a significantly higher NTS-to-AP ratio, reflecting a bias towards NTS-dominant engagement, whereas danuglipron and liraglutide yielded lower ratios that aligned with a more AP-skewed, nausea-like activation profile, in keeping with their distinct pharmacokinetic and signalling properties 7,8,9 (Fig