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A skin safety test performed in the United States showed that 52% of a group of 58 healthy volunteers became sensitized after exposure to MAL cream applied to the back under occlusion.7 The use of PDT in patients with nonsegmental Darier disease has been reported in 3 cases.810Exadaktylou et al.8 reported 5 cases treated with ALA-PDT

In addition to AGE and SAC, fresh garlic and its most bioactive component Allicin are also reported to elicit NO-dependent vasodilation

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