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Proteolytic Stability Attributed to D-Alanine and Studies have confirmed that Dermorphins D-Alanine at position 2 is the primary structural feature responsible for its enhanced proteolytic resistance compared to the all-L-amino acid analogue , with degradation studies documenting significantly slower enzymatic breakdown of Dermorphin compared to structurally similar L-amino acid peptides, confirming the functional significance of the D-amino acid in extending the peptides biological half-life

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