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SCFAs, such as acetate (C 2 ), propionate (C 3 ), and butyrate (C 4 ), are critical for epithelial barrier integrity, and anti-inflammatory signaling.Low levels are associated with IBD, cancer, obesity, diabetes, kidney disease, hypertension, liver disease, immune system dysfunction, and neurocognitive conditions

The GLP-1 drugs are the latest class to show a benefit in patients, this time with OSA, but like other tools have nontrivial side effects, cost concerns, and patient persistence issues that balance out the headline benefits. The size of the underlying patient populations, which are expected to surpass 1.3 billion globally by 2050, as well as the under penetration of CPAP treatment, which Andrew ballparks at 15% or less in many markets, reinforces the analysts argument