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Specifically, Ch2-Ch1 (B1-B2 map) RICS analysis of brightness (intensity of fluorescence signal) in one channel cross-correlates with brightness in the second channel, allowing for the calculation of cross-correlation

In the meantime, mitochondrial dysfunction is induced by hepatic IR and lipid accumulation and the lipid peroxidation mediated by cytochrome p450 2E1 boost the production of reactive oxygen and promote the degradation of mitochondria (125), which could further lead to the lack of cellular energy and metabolic intermediates accumulation, all these may lead to the secretion of pro-inflammatory cytokines, hepatocellular apoptosis and hepatic fibrogenesis, finally resulting in cirrhosis of the liver (125) ( Figure 3 )

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