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69 In comparison, newer oral small-molecule GLP-1 RAs, such as danuglipron and orforglipron, have demonstrated similar efficacy

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There are specific circumstances in which you should seek prompt medical advice, either from your trial team or your GP: Persistent insomnia lasting more than three to four weeks that is significantly affecting your daytime functioning, mood, or concentration Symptoms of anxiety or low mood that have developed or worsened since starting treatment, as these can both cause and be exacerbated by poor sleep Signs of obstructive sleep apnoea such as loud snoring, gasping during sleep (reported by a partner), or excessive daytime sleepiness which require formal assessment and may need referral to a sleep clinic New or worsening palpitations or an irregular heartbeat at night GLP-1-based medicines can be associated with a modest increase in resting heart rate

Remarkably high levels of proinflammatory interleukins are found in perilesional vitiligo skin and in the peripheral bloodstream [22]