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The Cochrane Collaboration, Chichester, UK: John Wiley & Sons

My energy, mood and attitude just changed, I may have been really deficient now that I think about it

co-administration of pyridoxine has been shown to reduce the blood levels of phenobarbital and phenytoin, possibly diminishing their anticonvulsant efficacy

While this hasnt been strongly replicated in humans, it could play a supporting role in long-term weight maintenance when combined with healthy habits