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Eli Lilly's primary rival in the weight-loss market is Novo Nordisk NVO, which markets its semaglutide (GLP-1) injections as Ozempic for T2D and Wegovy for obesity, competing directly with Mounjaro and Zepbound
In particular, CYP1A1 and 2E1, although playing a minor role in the overall metabolism, can be induced by PAHs making smokers more prone to severe ADRs (e.g., QT prolongation) due to increased metabolite concentrations
GLP-1 medications work on multiple systems in the body, which is why they produce such wide-ranging effects
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