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Breakthroughs in multi-omics technologies have confirmed that gut microbiota and their metabolites play a crucial role in regulating the pathological progression of IBD ( This review focuses on describing local intestinal iron metabolism, the regulation of iron homeostasis, and host-microbiota interactions based on current research findings, while also elucidating the underlying molecular mechanism of metabolite-modulated ferroptosis plasticity

Despite some limitations, such as efficient delivery and safety, CRISPRCas9 is still the most convenient tool for gene-editing purposes 34,35

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