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Kong et al., similarly uncovered synergy between a complex I inhibitor and a mito-antioxidant in cancer cells, suggesting their ability to reduce mitochondria-derived H 2 O 2 levels as a potential mechanism of action ( 2 O 2 levels increased after 24 hours of (M+D)/2 and (M+D+V)/3 treatments

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In pathological conditions, such as ALS, reactive astrogliosis occurs, in which astrocytes are modified both molecularly and morphologically [2125, 75]