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Clinical assessment should include a thorough history and examination to exclude other causes of persistent hiccups, such as gastro-oesophageal reflux disease (GORD), gastric distension, central nervous system pathology, metabolic disturbances, or medication interactions

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Reported Effects Synaptogenesis (in-vitro): Increased dendritic-spine formation in cultured hippocampal neurons the origin of the ~10-million BDNF ratio, now low-confidence because the source papers were retracted [4]