The right-hand panel shows the effect of semaglutide treatment on AKR1B10 levels in patients with MASH from a phase 2 trial population (semaglutide 0.1 mg [n = 80], semaglutide 0.2 mg [n = 78], semaglutide 0.4 mg [n = 82] and placebo [n = 80])
After multiple doses of oral semaglutide, the within-subject day-to-day variability was 2035% at steady state, with a higher total variability (consisting of within-subject day-to-day and between-subject variability) of up to 85%, suggesting some between-subject variability during oral semaglutide absorption (37)
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