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pubmed.ncbi.nlm.nih.gov/36415489 Monash Centre for Health Research and Implementation

female: n = 27,708)

In the body, GLP-1 acts as a multifunctional hormone with three main effects: Central appetite regulation: GLP-1 receptors in the brains appetite centres signal satiety, helping individuals feel full sooner and reducing cravings

Your provider should evaluate whether combination therapy offers additional benefit over single-agent escalation, or whether genetic and biomarker insights reveal you may respond very well to tirzepatide monotherapy at lower overall cost and complexity