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It manifests as localized fat accumulation and/or water retention, potentially accompanied by microcirculatory alterations

Boxplots showing the concentrations (y-axis) of the significantly altered metabolites in control (n = 9), compared to 50 (n = 9), 35x6 (n = 9), and 4+1 (n = 9) treatment groups analyzed by one-way ANOVA, p-value 0.1)

Increased liver weight, increased replicative DNA synthesis, and inhibition of gap-junction intercellular communication induced by a two-week treatment with diethlyhexyl phthalate or phenobarbital returned to control levels within one to four weeks following cessation of treatment (Isenberg et al