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10,11,81,82 Specifically, TLR-2, TLR-4, and the myeloid differentiation primary response protein 88 (MyD88) are crucial to the inflammatory reaction of macrophages to uric acid crystals

For decades, scientists have studied these short chains of amino acids, discovering that they act as biological messengers, signaling cells to perform specific functions

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Furthermore, in line with the beneficial effects of RAS blockers, researchers have also shown that the administration of empagliflozin, a SGLT2i, reduced the expression of IL-6, CCL2, and NF-B in the kidneys of diabetic Akita mice, as well as in cultured kidney tubular cells exposed to high glucose (195)