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Adv Lipid Res 1:335385 Deminice R, Rosa FT, da Silva LE, Jordao AA (2014) Taurine supplementation does not decrease homocysteine levels and liver injury induced by a choline-deficient diet

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Metformin treatment is associated with the increased presence of Akkermansia muciniphila in the gut lumen, which promotes the maintenance of intestinal barrier integrity, the increment of short-chain fatty acids with positive actions on peripheral tissues (adipose tissue, skeletal muscle, and liver) by improving insulin sensitivity [49,51,52], and reduced reabsorption of bile acids in the distal ileum, resulting in increasing bile salt levels within the colon, which might modify its microbiota [53,54] (Figure 1)