The sinuses experience nasal congestion, nosebleeds, and odor sensitivity
One of the cleaner ones, a 24-week randomized study of 279 mild-to-moderate Alzheimers patients, tested three doses against placebo and found a result no marketer would have designed: the lowest dose, 10 mL a day, beat placebo on both a cognitive scale and a global clinical rating, while the higher 30 and 60 mL doses improved the global rating but not cognition (Alvarez et al., Eur J Neurol 2006, randomized controlled trial)
For example, those with more severe deficiencies or certain health issues might need different doses
A systematic review and meta-analysis of 21 prospective cohorts and 6 nested case-control studies ( n = 49,707 cases and 1,274,060 individuals) indicated that a higher dietary intake of riboflavin, together with folate and vitamin B6 , might be associated with a decreased risk of estrogen and progesterone receptor-positive breast cancers 143