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PMID: 8227353 Secondary Connectivity Map / Broad Transcriptomics Gene Expression Modulation (4,048 Genes) Microarray and CMap analysis reveal that GHK-Cu modulates the expression of 4,048 genes in human fibroblast culturesapproximately 6% of the human genomeaffecting pathways for tissue remodeling, antioxidant defense, anti-inflammatory signaling, and stem cell markers

Specifically, skeletal muscle radical production increases as a function of both the exercise intensity and duration

This significantly reduces oxidative damage and apoptosis of brain microvascular pericytes, and increases the release of pericyte proangiogenic regulators ( Panax notoginseng in the repair of high-altitude hypoxia-related cerebral microcirculation disorders and neuroprotection

56 The MNAM together with their oxidized compounds, 4py and 2py, are eventually eliminated in the urine