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This article outlines what the current evidence suggests, key safety considerations for women, and what to discuss with your GP

Spiller HA, Winter ML, Klein-Schwartz W, et al

This is a big deal when you're using high-potency actives that can dramatically lower the pH of your skin

Realistic patterns: Months 1-2: 3-8 pounds (as dose increases) Months 3-6: 4-8 pounds per month at higher doses Months 7-12: 2-4 pounds per month (tapering is normal) Individual variation is massive