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A concussion is an "electrical storm" that disrupts normal brainwave patterns

Yet while reducing cardiovascular disease by treating high cholesterol, high blood pressure, and diabetes is standard practice, the concept of treating obesity to reduce cardiovascular complications has been hampered by the lack of evidence that lifestyle or pharmacologic interventions for overweight or obesity improve cardiovascular outcomes, said Michael Lincoff, M.D., SELECTs lead author and vice chair for research in Cleveland Clinics Department of Cardiovascular Medicine

Primary candidates include adults with type 2 diabetes and obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with weight-related comorbidities who have not achieved adequate glycemic control or weight loss goals with metformin monotherapy

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