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These benefits appear to reflect both improvements in traditional risk factors - weight, blood pressure, lipid profiles, glycemic control - and potentially direct cardioprotective effects mediated by GLP-1 receptors expressed in cardiomyocytes and vascular endothelium

This helps reduce the rare risk of lactic acidosis

In contrast, the injection group may have experienced higher peak concentrations followed by a rapid decline, resulting in the less consistent regulation of neuropeptide expression

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