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TL;DR Rybelsus (oral semaglutide) is a GLP-1 receptor agonist that delivers stronger weight loss (12-15% of body weight) and A1C reduction (-1.8%) than metformin (3-5% weight loss, -1.5% A1C), but costs roughly $936-$998 per month compared to metformins $4-$10 generic price

The TBI + Vehicle continued to show diminished index of recognition compared to Sham + Vehicle

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Serious but rare side effects (such as pancreatitis or thyroid tumours) are also similar and require medical attention if symptoms appear 3 , 4