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N Engl J Med 385(16):14511461 Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF et al (2022) Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction

The electrophilic nature of SFN drives its direct conjugation with glutathione, effectively depleting intracellular GSH pools and consequently inhibiting glutathione peroxidase 4 (GPX4) activity

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Glutathione precursors: Consuming foods or supplements rich in glutathione precursors (like N-acetylcysteine or alpha-lipoic acid) throughout the day can support your body's natural glutathione production without directly competing with coffee absorption