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The FTO gene (rs9939609) and MC4R gene (rs17782313) variants also shape appetite regulation and energy metabolism, affecting how both medications perform in your system

Hormonal changes, certain medical conditions like Cushings syndrome and Marfan syndrome, and even the use of corticosteroid medications can further increase your risk by affecting your skins strength and elasticity

One of the most pivotal studies supporting the FDA approval of semaglutide for chronic weight management is the STEP 1 clinical trial

**Potential Risk of Pancreatitis**: While rare, there have been reports of pancreatitis in some patients taking these medications