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Curcumin showed a protective antioxidant effect against gentamycin-induced oxidative stress documented by alleviated lipid peroxides, increased levels of superoxide dismutase and glutathione, increased expression of Bcl-2, a protein protecting against oxidative stress, suppressed proapoptotic Bax, and suppressed executioner caspase in apoptosis, caspase-3

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I am considering going back down to 6mg a week on reta since i think the 8mg a week on reta is counter acting the appetite suppression of cagri