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Research has investigated the mechanisms by which NNMT inhibition might increase energy expenditure, potentially through effects on mitochondrial function or uncoupling protein expression

Goldblatt MI, Swartz-Basile DA, Choi SH, Rafiee P, Nakeeb A, Sarna SK, Pitt HA

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The findings from its phase IV trial (NCT05312268) indicated that the combination of rasburicase with oral uratelowering medications achieved shortterm normalization of serum urate levels