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Por ejemplo, semaglutida 2.4 mg (Wegovy) y tirzepatida (Zepbound) pueden lograr reducciones de 10-15% o ms, mientras que otros agentes a dosis para diabetes suelen producir prdidas ms modestas

Similar caution applies to more recent short-term combination studies reporting improvements in ovulation, endocrine markers, or related reproductive parameters, because endpoint definitions, denominators, concomitant therapies, and follow-up windows varied across trials (103, 104)

The GLP-1 crunch

While significant progress has been made in understanding how the central nervous system processes individual states such as fear 4 , pain 5,6 , hunger 5 , and thirst 6 , the mechanisms by which the brain hierarchically organizes competing survival demands remain poorly understood