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"Folate and vitamin B12: friendly or enemy nutrients for the elderly"

For example, one study looking at relatively high doses (0.1-0.3g/kg/day) saw no meaningful improvements in the creatine group compared to placebo in a full suite of exercise measures.18 Another yearlong study, in participants between 49 and 67 taking 0.1g/kg/day, looked at bone density and muscle strength and found only one slight difference favoring the creatine group in a single measure of bone bending strength.37 This evidence points to the likelihood that supplemental creatine is less effective in older populations, though the reasons for this arent firmly established

Clinical response: Confirm medication adherence and dietary habits, evaluate for fluid overload, and consider additional interventions or medication adjustments

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