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By systematically reviewing the neurotoxic mechanisms, clinical manifestations, and therapeutic interventions associated with these six drugs, this study aims to provide insights into the current knowledge gaps and potential avenues for future research

Medications know to cause bone marrow suppression (e.g., myelosuppressive antineoplastic agents) may result in a blunted or impeded response to methylcobalamin, vitamin B12 therapy

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These appear to be dose-dependent and typically resolve with dose reduction