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Our findings propose another paradigm where ACE2 acts as a receptor-like protein, since pharmacological inhibition, as well as downregulation of ACE2 inhibited SARS-CoV-2 spike-induced inflammation, without any changes in ACE2 activity after exposure of human endothelial cells to the recombinant spike protein

This study provided the first experimental evidence for the anti-inflammatory and immunomodulatory properties of GLP1

Over-the-counter NSAIDs (like ibuprofen , often prescribed at higher doses) also contribute

The review further noted that MC1R activation may promote anti inflammatory signaling independently of melanin synthesis, suggesting that receptor engagement may produce context dependent outcomes based on ligand structure and cellular environment