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A 2024 double-blind randomized trial of 156 participants with early Parkinsons disease found that participants receiving a GLP-1 drug, lixisenatide, showed no progression of motor symptoms, compared to a measurable worsening on standard motor scales in the placebo group

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GLP-Squared Injection (dual semaglutide-tirzepatide compound) is $289/mo month-to-month (or $249/mo on the 3-month plan) and may offer synergistic benefits without the need for a separate opioid antagonist

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