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Disulfiram, which was originally used as an antialcoholism drug, has been repurposed to inhibit ALDH and disrupt redox balance in CSCs, leading to increased sensitivity to chemotherapy and radiotherapy

Authors : Enrico Gerace, Jessica Modaffari, Pierre Negri, Daniele Di Corcia, Eleonora Amante, Alberto Salomone, Marco Vincenti Source : A simple and effective procedure based on a fast methanolic extraction and a LC-HRMS detection of the growth hormone secretagogue ipamorelin in DBS was recently proposed by Gerace et al

Instead, they may rely more heavily on cheaper, processed foods that lack essential nutrients

These challenges highlight the requirement for an improved delivery system that can overcome the BBB and facilitate targeted delivery to specific pathological brain regions or cell types