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Studies have reported tolerability and acceptable side effects of toxin-conjugated fusion proteins, as well as great anti-tumor effects in bladder, head and neck cancers, and epithelial tumors, which has led them to the next stages of clinical trials [204,205,206]

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The Ca axis is associated with activation of phospholipase C or GMP-specific phosphodiesterase, followed by the release of intracellular Ca into the cytosol to activate downstream signaling proteins consisting of CREB and NFAT transcription factors mainly to regulate migration [90, 92]